Dipartimento di Scienze chimiche, farmaceutiche ed agrarie https://old.scf.unife.it These are the search results for the query, showing results 1 to 15. Research https://old.scf.unife.it/en/research/research The Department includes the following main scientific research areas:

ANALYTICAL and  ENVIRONMENTAL CHEMISTRY

PHYSICAL and COMPUTATIONAL CHEMISTRY

PHARMACEUTICAL CHEMISTRY, PHARMACEUTICAL TECHNOLOGY

PHOTOCHEMISTRY and INORGANIC AREAS

ORGANIC and INDUSTRIAL CHEMISTRY

FOOD and NUTRACEUTICAL CHEMISTRY

The research activities are co-financed by structural founds on a national level and by Italian and foreign privately owned companies.

Recent examples include Italian Ministry for University PRIN and FIRB calls, a POR-FESR (2014-2020) project and a Marie Skłodowska-Curie action.

 

Many agreements have been signed with various Companies as a token to demonstrate the attractiveness of the Department.

]]> No publisher amministratore 2016-07-08T11:45:00Z Page International https://old.scf.unife.it/en/international/international The Department of Chemical and Pharmaceutical Sciences is firmly committed to provide international training and education. Students can therefore take advantage of various opportunities for learning in an international context.

The Department of Chemical and Pharmaceutical Sciences offers the Ferrara School of Chemistry and Ferrara School of Medicinal Chemistry, a diploma of excellence for the best students with international curricula. All the related information can be found at the following link.

Students are deeply encouraged to partecipate to exchange programs for studying and to prepare their thesis abroad by european Universities (Erasmus+ for study) and extra-UE (Atlante program, Atlante "C" program). Students can also apply for stages by private companies (Erasmus+ CON.C.E.R.T.O. ed Erasmus+ Traineeship). Detailed info are available at: http://www.unife.it/studenti/en/international-services.

Similar opportunities are given also to researchers and professors (Mobilità docenti/PTA/esperti).

]]> No publisher amministratore 2016-05-31T12:30:00Z Page Business & Innovation https://old.scf.unife.it/en/companies-and-territory No publisher Iazzetta Salvatore 2016-05-31T12:25:00Z Folder International https://old.scf.unife.it/en/international No publisher amministratore 2016-05-30T07:04:23Z Folder Higher Education Doctorate https://old.scf.unife.it/en/companies-and-territory/higher-education-doctorate A three-year doctoral grant is funded by the Regione Emilia-Romagna (for a graduate student working on activities with high level qualification) from the European Social Fund with a project entitled “Development and optimization of bio-colorants from agri-food byproducts for the construction of architecturally integrated solar cells for sustainable housing", scientific advisors: Prof. Alessandro Massi, Prof. Stefano Caramori.

 

This project envisages the training of a scientific/professional figure having expertise in the second-generation valorization of agri-food by-products (organic pigments) applied to the realization of solar cells. The project falls within the Emilia-Romagna declared value chains concerning the development of photoelectrochemical devices for conversion of solar energy and, in general, of the indoor and outdoor architectural light energy. This is fully in line with the aims of the value chain LOW CARBON ECONOMY (LowCarbon ER) regarding the transition of the regional economy to a better environmental sustainability. At the same time, the project has a bearing on the value chain AGRIFOOD (SPES, Valorization of byproducts and waste) which focuses on the use of waste and byproducts from agro-food industry for the production of medium/high-added value molecules, namely bio-colorants and their chemical derivatives, able to absorb and convert solar energy into electricity in transparent photoelectrochemical cells based on TiO2 (titanium dioxide) substrates. Besides, the visual characteristics of the solar cells which will be built (transparency, available color palette) provide for their integration as architectural features. This takes place within the framework of home energy recovery, with cells being possibly used as outdoor devices (integration in windows and glass walls) and indoor apparatus for the intelligent energy management (gobo, etc.), and also as energy source for smart home, sensor applications, rechargeable devices etc. (Value Chain G2B, Energy Efficiency and Sustainability in Construction). It should be noted that these solar cells give beneficial use, compared to the ones based on silicon, in soft light (autumn and winter months in the region) and diffuse light conditions, allowing recovery of in-house low energy with an efficiency greater than 20%.

]]> No publisher Lodi Enrico 2019-03-04T16:08:43Z Page Helix Recovery Project https://old.scf.unife.it/en/companies-and-territory/helix-recovery-project Recover of waste mucus from snail farming.

The project seeks to recover the mucus secreted by snails reared in Sardinia Region for gastronomic application in order to enhance the value of snail farming. It is planned to characterize the mucus and its derivatives in chemical, microbiological and functional terms to generate a certified supply chain under which lay a scientific characterization of mucus properties, which up to now have not been fully demonstrated. This work is expected to allow valorization of an industrial waste, i.e. mucus, with the aim of making it marketable in cosmetic, nutraceutical and pharmaceutical areas.

]]> No publisher Lodi Enrico 2019-02-28T11:43:51Z Page Department Council https://old.scf.unife.it/en/about-us/department-council Full Professors

Associate Professors

Researcher

Members of Technical Staff

Members of Research Fellow

]]> No publisher Iazzetta Salvatore 2019-03-08T12:41:16Z Page Interaction And Recognition In Molecular Crystals https://old.scf.unife.it/en/research-and-third-mission/reseach/research/physical-and-computational-chemistry/Interaction-And-Recognition-In-Molecular-Crystals Molecular crystals are ideal models for the study of molecular interaction forces that are responsible for the different aggregation states of matter and which are important for supramolecular recognition processes relevant in chemistry, material science and biochemistry of the drug-receptor and enzyme-substrate interactions. The study of crystal packing within extended series of crystals (either designed ad hoc or derived from systematic investigation of crystallographic databases, also possibly integrated with thermodynamic and spectroscopic data as well as computational calculations) allows for the identification of intermolecular recognition forces that enable molecule to be part of stable aggregated species. The data analysis is performed with LFER (linear free-energy relationships) and structural correlation methods aimed at the definition of the reaction pathways and the identification of structure/properties relationships.

 

Goals

  1. Systematic study of hydrogen bonding, its classification in chemical classes and formulation of general models capable of predicting the properties, with particular regard to structure and energetic.
  2. Application of strong hydrogen bonding in chemistry, biochemistry, and material science.
  3. Systematic study of charge transfer interactions in molecular crystals. Their importance in the determination of the crystal packing and in the definition of a general theoretical basis for molecular interactions.
  4. Application of the understanding of the molecular interactions towards crystal engineering, with particular regard towards functional materials and co-crystals of pharmaceutical interest.

 

Instruments and Methods

Systematic use of crustallographic and theromdynamic databases. Simulation of model molecules by quantum chemistry with either “ab initio” or DFT methods. Preparations of molecular crystals and co-crystals for the study of molecular interactions and their structural determination by X-ray diffraction technique at both room and cryogenic temperature.

 

Main Subjects

Structural chemistry; Physical chemistry; General chemistry.

 

Research Group

  • Valerio Bertolasi
  • Paola Gilli

 

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]]> No publisher Lodi Enrico 2019-02-25T21:35:02Z Page StructuralStudyPotentialMetalBasedDrugs https://old.scf.unife.it/en/research-and-third-mission/reseach/research/physical-and-computational-chemistry/STRUCTURALSTUDYOFPOTENTIALMETALBASEDDRUGS.pdf No publisher Lodi Enrico 2019-02-25T21:45:05Z File Study And Characterization Of Molecular Magnets https://old.scf.unife.it/en/research-and-third-mission/reseach/research/physical-and-computational-chemistry/Study-Characterization-Molecular-Magnets The project deals with the study of the interactions between metal centers within polynuclear molecular complexes. Polynuclear complexes are multi-functional materials and, among them, those containing copper are particularly interesting due to their multiple properties. Indeed, they can mimic active sites of natural biomolecules, they can interact with DNA, or they can be used as innovative materials in chemistry and in nanotechnologies thanks to their featuring electronic, magnetic, and redox properties.

 

Goals

The main goal is to start a systematic study of the magnetic properties of bi- and tri-nuclear copper and nickel complexes. The interest towards these systems arises from the fact that oxygen atoms of specific ligands can act as bridges between copper centers. Since there is a strong relationship between the molecular structure (particularly metal coordination and structure of bridges) and the nature and intensities of the magnetic interactions between unpaired electrons in the metal centers, an accurate choice of organic ligands may induce a direct modulation of the magnetic properties.

 

Instruments and Methods

  • Development of synthetic strategies for the preparation of polynuclear complexes;
  • Structural characterization with X-ray diffraction techniques;
  • Study of the magnetic properties via SQUID (Superconducting Quantum Interference Devices);
  • EPR spectroscopy;
  • Application of theoretical and computational strategies for the appropriate description of the electronic structure and the magnetic properties.

 

Main Subjects

Physical chemistry, Inorganic chemistry; Spectroscopy; Theoretical chemistry.

 

Research Group

  • Valeria Ferretti
  • Celestino Angeli

 

Collaborations

  • Prof. F. Spizzo (Department of Physics and Earth Sciences, UNIFE)
  • Prof. C. J. Calzado (Departamento de Química Física, Universidad de Sevilla, Spain)
  • Prof. R. P. Sharma (Department of Chemistry, Punjab University, Chandigarh, India)
  • Prof. A. Ozarowski (National High Magnetic Field Laboratory, Florida State University, USA)

 

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]]> No publisher Lodi Enrico 2019-02-25T21:54:51Z Page Organic Chemistry https://old.scf.unife.it/en/research-and-third-mission/reseach/research/organic-chemistry No publisher Lodi Enrico 2019-02-27T21:50:46Z Folder ArtificialNucleosides https://old.scf.unife.it/en/research-and-third-mission/reseach/research/organic-chemistry/ARTIFICIALNUCLEOSIDES.pdf No publisher Lodi Enrico 2019-02-27T21:50:25Z File Artificial Nucleosides https://old.scf.unife.it/en/research-and-third-mission/reseach/research/organic-chemistry/Artificial-Nucleosides This research area involves the design, synthesis, and the study of the biological activity of artificial (modified) nucleosides and nucleotides. Such compounds have been largely used for medicinal chemistry (e.g. antiviral and anticancer agents) and chemical biology (e.g. study of enzyme reactions) applications. Furthermore, oligonucleotides containing modified nucleotides have been employed for advanced gene therapy studies and as probes for molecular recognition interactions.

 

Goals

  • Synthesis of nucleoside-conjugates of bile acid derivatives.
  • Synthesis of artificial glycosylnucleotide analogues.
  • Solid phase synthesis of highly modified oligonucleotides for in vitro and in vivo (animal model) applications.

 

Instruments and Methods

Fully automated oligonucleotide synthesizer for synthesis in 1-50 μM and 150 μM-9 mmol ranges. HPLC systems. Mass (MS) spectrometry, UV spectroscopy and nuclear magnetic resonance (NMR).

 

Main Subjects

Organic chemistry; pharmacology; molecular biology.

 

Research Group

  • Daniela Perrone
  • Marco Fogagnolo

 

Collaborations

  • Prof. P. Merino (University of Zaragoza, Spain)
  • Prof. A. Dalpiaz (University of Ferrara)
  • Dr. M. Capobianco (CNR-ISOF, Bologna)
  • Prof. R. Gavioli (University of Ferrara)
  • Dr. Matteo Bovolenta (Gènèthon, Évry, France)
  • Prof. S. Fiorucci (University of Perugia)
  • Prof. G. Sorci (University of Perugia)

 

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]]> No publisher Lodi Enrico 2019-02-27T21:50:47Z Page Biocatalysis https://old.scf.unife.it/en/research-and-third-mission/reseach/research/organic-chemistry/BIOCATALYSIS.pdf No publisher Lodi Enrico 2019-02-27T22:00:02Z File Biocatalysis https://old.scf.unife.it/en/research-and-third-mission/reseach/research/organic-chemistry/Biocatalysis This line of research focuses on the use of biocatalyzed processes for the production of optically active chiral molecules and biologically active compounds derived from natural products. Typically, biocatalysts are enzymes of bacterial origin which are extracted and purified or more often cloned and expressed in suitable recombinant bacteria. Enzymes are ideal catalysts for the development of processes with a low environmental impact, due to their proteinous nature, their ability to promote transformations in aqueous media (but not only) at temperature < 100 °C and, above all, their selectivity (which limits byproducts formation). The sustainability of biocatalyzed transformations may be further expanded through catalyst immobilization onto natural (synthetic) polymer matrices by covalent bonding. An immobilized enzyme has some distinguishing advantages, such as greater stability and ease of separation from the reaction mixture, which allow its reuse in several reaction cycles (with clearly economic benefits).

 

Goals

  • Development of synthetic methodologies based on the use of carboligases (C-C bond-forming reactions), dehydrogenases (reduction of prochiral ketones) and lipases (transesterification reactions).
  • Study of reactions involving the combined use of diverse enzymes or enzymes and organocatalysts.
  • Study of biocatalyzed processes in both batch and continuous flow modes in the presence of immobilized enzymes.

 

Instruments and Methods

Mass (MS) spectrometry and infrared (FT-IR) spectroscopy. Nuclear magnetic resonance (NMR). Elemental analysis. Chromatographic instruments.

 

Main Subjects

Organic chemistry; biochemistry.

 

Research Group

  • Olga Bortolini
  • Alessandro Massi
  • Marco Fogagnolo
  • Giancarlo Fantin
  • Pier Paolo Giovannini
  • Daniele Ragno
  • Carmela De Risi

 

Collaborations

  • Prof. M. Muller (University of Fribourg, Germany)
  • Prof. D. de Oliveira (Universidade Federal de Santa Catarina, Brasil)
  • Dott. G. Bernacchia, Dott. N. Marchetti (University of Ferrara)

 

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